Beyond Health Resource Article:

Libido and Vaginal Health Across the Lifespan: Understanding Changes, Pain, and Modern Treatments

Libido and Vaginal Health Across the Lifespan: Understanding Changes, Pain, and Modern Treatments Image

By Dr. Steven Long, DO, MHA, CPT
Beyond Health | Precision Medicine for High-Performance Living

Sexual health is one of the most under-discussed aspects of women’s wellness.
Many women experience changes in libido, vaginal comfort, and sexual satisfaction throughout life — but too often, these changes are dismissed as “normal aging” rather than treatable physiologic changes.

At Beyond Health, we view sexual health as a vital component of longevity, metabolic wellness, and quality of life. Sexual function is not merely hormonal; it reflects vascular, neurological, psychological, and relational well-being.

Understanding why these changes occur — and how modern medicine can help — allows women to take control of this important part of their healthspan.

1. Libido Through the Female Lifespan

Libido (sexual desire) is a complex interplay of hormones, neurotransmitters, vascular health, and emotional connection. It fluctuates naturally with age, reproductive stage, stress, and health status.

Reproductive Years

During the 20s and 30s, libido tends to be higher due to robust levels of estrogen, progesterone, and testosterone. These hormones enhance vaginal lubrication, clitoral sensitivity, and sexual motivation.

Pregnancy and postpartum, however, often cause temporary declines in libido due to hormonal shifts, exhaustion, and altered body image.

Perimenopause

Starting in the 40s, estrogen and testosterone begin to decline. This leads to:

  • Decreased vaginal lubrication
  • Reduced genital sensitivity
  • Thinning of vaginal and vulvar tissue
  • Mood fluctuations that impact sexual desire

Menopause and Beyond

After menopause (defined as 12 months without a period), estrogen levels fall by 80–90%, and androgen levels continue to decline gradually.
The result is often a cluster of symptoms known as Genitourinary Syndrome of Menopause (GSM) — a condition that affects up to 50% of postmenopausal women (Portman & Gass, Menopause, 2014).

2. Understanding Genitourinary Syndrome of Menopause (GSM)

GSM is a comprehensive term that replaces “vulvovaginal atrophy,” reflecting a broader understanding of how estrogen deficiency affects multiple tissues in the lower genitourinary tract.

Common GSM Symptoms

  • Vaginal dryness or burning
  • Pain with intercourse (dyspareunia)
  • Decreased elasticity or narrowing of the vaginal canal
  • Recurrent urinary tract infections
  • Urinary urgency or leakage

These symptoms are not simply inconveniences — they can severely impact intimacy, mood, and quality of life.

Pathophysiology

Estrogen maintains vaginal tissue thickness, elasticity, and vascularity. When estrogen declines:

  • Collagen production decreases.
  • Vaginal pH rises, disrupting protective lactobacilli.
  • Epithelial layers thin, and microabrasions occur during intercourse.

This environment fosters dryness, discomfort, and increased infection risk — but these changes are reversible with appropriate treatment.

3. Pain With Sex (Dyspareunia): Why It Happens

Pain during intercourse is one of the most common and distressing symptoms of GSM.
 Dyspareunia can arise from multiple factors:

Category

Examples

Hormonal

Low estrogen or androgens → tissue thinning, dryness

Mechanical

Vaginal narrowing, pelvic floor dysfunction

Inflammatory

Recurrent infections, skin conditions (lichen sclerosus)

Psychological

Fear, anxiety, prior pain conditioning

Medication-related

SSRIs, antihistamines, chemotherapy, anti-estrogens

Over time, pain can create a feedback loop — fear of pain leads to avoidance, decreased arousal, and further tissue deconditioning.

Breaking this cycle requires addressing both the physical and psychological components, often through local therapy, pelvic floor work, and hormonal restoration.

4. Hormones, Libido, and Vaginal Health

Estrogen

Estrogen is the primary regulator of vaginal health.
 It promotes:

  • Blood flow to genital tissue
  • Collagen and elastin synthesis
  • Vaginal lubrication and epithelial integrity
  • Urethral and bladder function

Estrogen therapy — especially local (vaginal) formulations — can restore pH, thickness, and lubrication within weeks, dramatically reducing pain and dryness.

Testosterone

While often overlooked, androgens play a key role in female sexual function.
 Testosterone influences:

  • Desire and arousal
  • Clitoral sensitivity
  • Energy and motivation

Postmenopausal women typically experience 50% lower testosterone than during reproductive years. Carefully monitored replacement therapy may improve libido and satisfaction (Islam et al., JAMA Intern Med, 2019).

DHEA (Dehydroepiandrosterone)

DHEA is an adrenal hormone that can be converted into estrogen and testosterone within tissues.
Vaginal DHEA (prasterone) has been shown to:

  • Improve vaginal elasticity and lubrication
  • Increase sexual desire and reduce dyspareunia
  • Avoid significant systemic absorption

Studies show daily 6.5 mg vaginal DHEA is safe and effective for GSM (Labrie et al., Menopause, 2016).

5. Treatment Options for GSM and Libido Changes

1. Local Vaginal Estrogen

  • Forms: creams, tablets, rings, or inserts.
  • Effect: restores vaginal pH, tissue thickness, and elasticity.
  • Safety: minimal systemic absorption; not associated with increased breast cancer or cardiovascular risk (Rahimi-Ardabili et al., Climacteric, 2022).

Benefits:

  • Reduces pain, dryness, and urinary symptoms.
  • Improves sexual comfort and function.

2. Systemic Hormone Replacement Therapy (HRT)

  • Indicated for broader menopausal symptoms (hot flashes, mood, sleep, cognition) along with GSM.
  • Combined estrogen-progesterone therapy supports vaginal and systemic health.
  • Best results when initiated within 10 years of menopause (the “window hypothesis”).

3. Vaginal DHEA (Prasterone)

  • Stimulates local estrogen and androgen receptors.
  • Improves lubrication, elasticity, and libido without systemic hormone spikes.

4. Non-Hormonal Lubricants and Moisturizers

  • Silicone- or water-based products for symptom relief.
  • Used adjunctively, not as substitutes for hormone restoration.

5. Pelvic Floor Physical Therapy

  • Addresses pain from pelvic muscle tension or scarring.
  • Improves blood flow, relaxation, and sexual confidence.

6. Behavioral and Lifestyle Optimization

  • Regular exercise improves pelvic circulation and endorphin release.
  • Adequate protein intake supports hormone production and tissue repair.
  • Reducing alcohol and stress improves arousal and mood.

6. Addressing Libido Holistically

Low libido is rarely just hormonal — it reflects a combination of:

  • Hormone changes
  • Stress and sleep deprivation
  • Relationship dynamics
  • Psychological or past trauma
  • Medications (SSRIs, oral contraceptives, etc.)

At Beyond Health, our approach is comprehensive:

  1. Assess hormones: estradiol, progesterone, testosterone, SHBG.
  2. Evaluate vascular and metabolic health: lipid profile, inflammation, thyroid.
  3. Address stress and sleep: cortisol and circadian rhythm optimization.
  4. Individualize therapy: restoring physiology, not just treating symptoms.

We combine evidence-based medicine with personalized interventions — from vaginal estrogen and DHEA to pelvic floor therapy referral and behavioral support — to restore sexual function as part of whole-body health.

7. Beyond Health’s Perspective

Sexual function is an essential marker of health and vitality.
 Loss of libido or painful intercourse should never be dismissed as “just aging.”

At Beyond Health, we view these symptoms as biological feedback, signaling the need for tissue restoration, hormone balance, and improved vascular and metabolic support.

Our approach integrates:

  • Local therapy for tissue rejuvenation
  • Systemic optimization through HRT or DHEA when appropriate
  • Muscle and mobility training for pelvic health
  • Emotional and relational support for confidence and intimacy

Because sexual health isn’t vanity — it’s vitality.

Conclusion

Changes in libido, vaginal comfort, and sexual satisfaction are common — but they are not inevitable.
 With modern evidence-based therapies, women can restore vaginal health, relieve pain, and reclaim desire at any stage of life.

Vaginal estrogen, DHEA, and tailored hormone therapy are safe, effective, and life-enhancing when prescribed responsibly.
 When paired with physical therapy, metabolic health, and lifestyle optimization, they form a comprehensive blueprint for longevity and fulfillment.

At Beyond Health, our mission is to ensure that women not only live longer — but live better, with strength, confidence, and connection at every stage.

References

  1. Portman DJ, Gass ML; Vulvovaginal Atrophy Terminology Consensus Conference Panel. Genitourinary Syndrome of Menopause: New Terminology for Vulvovaginal Atrophy From the International Society for the Study of Women’s Sexual Health and The North American Menopause Society. Menopause. 2014;21(10):1063–1068.
  2. Labrie F, et al. Effect of Intravaginal DHEA on Vaginal Atrophy in Postmenopausal Women: A Randomized Controlled Trial. Menopause. 2016;23(3):243–256.
  3. Islam RM, et al. Safety and Efficacy of Testosterone for Women: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2019;179(9):1173–1180.
  4. Rahimi-Ardabili B, et al. Vaginal Estrogen Use and Chronic Disease Risk in Postmenopausal Women: Findings from the Nurses’ Health Study. Climacteric. 2022;25(4):381–389.
  5. Parish SJ, et al. The International Society for the Study of Women’s Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women. J Sex Med. 2021;18(5):849–867.
  6. Santoro N, et al. Perimenopause: From Bench to Bedside. Front Endocrinol (Lausanne). 2021;12:688628.
  7. Simon JA. Clinical Effects of Vaginal Estrogens: Beyond the Genitourinary Tract. Menopause. 2018;25(9):1042–1051.
  8. Shifren JL, Gass ML. The North American Menopause Society Recommendations for Clinical Care of Midlife Women. Menopause. 2014;21(10):1038–1062.

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